OncologyTargeting de novo lipogenesis and the Lands cycle induces ferroptosis in KRAS-mutant lung cancer By Graviton / 07/2022 Nature Communications
NASHA baseline signature of metabolites involving the gut-liver axis predicts MRI-PDFF response to FASN inhibitor TVB-2640 in NASH patients: results from the FASCINATE-1 study By Graviton / 06/2022 EASL International Liver Congress
NASH, PUBLICATIONSNovel, first-in-class, fatty acid synthase (FASN) inhibitor TVB-2640: efficacy, safety and biomarker results from a global phase 2 randomized pbo-controlled NASH trial, FASCINATE-1 By Graviton / 05/2022 Digestive Disease Week
NASHNovel, first-in-class, fatty acid synthase (FASN) inhibitor TVB-2640 demonstrates robust clinical efficacy and safety in a global phase 2 randomized placebo-controlled NASH trial (FASCINATE-1) By Graviton / 01/2022 NASH-TAG
OncologyTherapeutic efficacy of FASN inhibition in preclinical models of HCC By Graviton / 01/2022 Hepatology
NASHTVB-2640, a novel, first-in-class, fatty acid synthase (FASN) inhibitor: biomarker and metabolomic correlations with clinical MRI-PDFF response By Graviton / 11/2021 NASH Summit
NASHNovel, first-in-class, fatty acid synthase (FASN) inhibitor TVB-2640 demonstrates robust clinical efficacy and safety in a global phase 2 randomized placebo-controlled NASH trial (FASCINATE-1) conducted in the U.S. and China By Graviton / 11/2021 AASLD The Liver Meeting
NASHTranslation of FASN Inhibitor TVB-2640 from Preclinical MOA to Clinical POC in NASH By Graviton / 09/2021 NASH and Fibrosis Conference
NASHTVB-2640 (FASN inhibitor) for the treatment of nonalcoholic steatohepatitis: FASCINATE-1, a randomized, placebo-controlled Ph2a trial By Graviton / 07/2021 Gastroenterology
NASHAnalysis of non-invasive biomarker tests in the Phase 2 FASCINATE-1 study of FASN inhibitor TVB-2640 By Graviton / 06/2021 EASL International Liver Congress