A clinical-stage pharmaceutical company developing novel therapeutics to treat important diseases such as non-alcoholic steatohepatitis (NASH) and various cancers. Our expertise in FASN enables us to break new ground in targeting dysfunctional metabolic pathways.

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We’ve created a platform of proprietary, selective FASN inhibitors. Our lead product candidate TVB-2640 is an oral, highly potent, selective and reversible, first-in-class FASN inhibitor. TVB-2640 is rapidly absorbed in the human body with well-behaved pharmacokinetics.

Pipeline

FASN Inhibitor

Indication

Preclinical

Phase 1

Phase 2

Phase 3

TVB-2640

NASH

Title

58%

TVB-2640

Oncology

Title

58%

TVB-3567

Undisclosed

Title

22%

FASN Inhibitor – TVB-2640

Indication – NASH

Phase 2

Title

70%

FASN Inhibitor – TVB-2640

Indication – Oncology

Phase 2

Title

70%

FASN Inhibitor – TVB-3567

Indication – Undisclosed

Preclinical

Title

30%

Posters & Publications

September 9, 2020 in Virology

Virology Placeholder post

(Poster presented at AACR-NCI-EORTC Meeting on Saturday, Nov 7, 2015)
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August 27, 2020 in NASH

Novel, first-in-class, fatty acid synthase inhibitor, TVB-2640 versus placebo demonstrates clinically significant reduction in liver fat by MRI-PDFF in NASH

(Oral presentation, EASL International Liver Congress, 27-29 August 2020, Abstract #AS074)
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August 27, 2020 in NASH

The FASN inhibitor TVB-2640 is efficacious in a new 3D human liver microtissue model of NASH

(Poster, EASL International Liver Congress, 27-29 August 2020, Abstract #SAT038)
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