NASHPharmacologic Inhibition of FASN Reverses Diet-Induced Steatohepatitis in Mice and Inhibits Lipogenesis in Humans. By Graviton / 10/2017 AASLD
NASHEstablishing the foundation for a novel, first-in-class, fatty acid synthase inhibitor, TVB-2640, for the treatment of NASH By Graviton / 04/2017 EASL International Liver Congress
OncologyHeavily Pre-Treated Breast Cancer Patients show Promising Responses in the First in Human Study of the First-In-Class Fatty Acid Synthase (FASN) Inhibitor, TVB-2640 in Combination with Paclitaxel By Graviton / 12/2016 San Antonio Breast Cancer Symposium
NASHPharmacological inhibition of FASN Prevents High Fat Diet Induced Liver Damage in Mice and Significantly Reduces de novo Lipogenesis in Humans By Graviton / 11/2016 AASLD The Liver Meeting
OncologyPreliminary Activity in the First in Human Study of the First-In-Class Fatty Acid Synthase Inhibitor, TVB-2640 By Graviton / 11/2016 NCRI Cancer Conference
OncologyPreliminary Activity in the First in Human Study of the First-In-Class Fatty Acid Synthase (FASN) Inhibitor, TVB-2640 By Graviton / 06/2016 ASCO Annual Meeting
OncologyFASN inhibitor TVB-2640 shows pharmacodynamic effect and evidence of clinical activity in KRAS mutant NSCLC patients in a Phase 1 study By Graviton / 04/2016 AACR Annual Meeting
OncologyPreclinical studies characterize tumor type sensitivity to FASN inhibition and the mechanism and efficacy of novel drug combinations with TVB-2640 By Graviton / 04/2016 AACR Annual Meeting
OncologySebum Analysis from Dose Escalation and Expansion Phases of the FASN Inhibitor TVB-2640 Phase 1 Trial, A Non-Invasive Biomarker of Target Engagement By Graviton / 02/2016 Keystone Symposium – New Frontiers in Understanding Tumor Metabolism
OncologyA First in Human Study of the First in Class Fatty Acid Synthase (FASN) Inhibitor TVB-2640. Results of Dose Escalation in Mono and Combination and Evidence of Preliminary Activity By Graviton / 11/2015 EORTC-NCI-AACR International Conference