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Oncology

Fatty acid synthase inhibitor TVB-3664 reverses multiple components of diet-induced nonalcoholic steatohepatitis in mice treated with or without co-administered pirfenidone and reduces collagen accumulation in bleomycin-induced murine skin fibrosis

By Graviton / 10/2017

AASLD

First in human study of the first-in-class fatty acid synthase (FASN) inhibitor TVB-2640

By Graviton / 04/2017

AACR Annual Meeting

Fatty Acid Synthase – Modern Tumor Cell Biology Insights into a Classical Oncology Target

By natalia / 02/2017

Pharmacology and Therapeutics

Heavily Pre-Treated Breast Cancer Patients show Promising Responses in the First in Human Study of the First-In-Class Fatty Acid Synthase (FASN) Inhibitor, TVB-2640 in Combination with Paclitaxel

By Graviton / 12/2016

San Antonio Breast Cancer Symposium

FASN inhibition and taxane treatment combine to enhance anti-tumor efficacy in diverse xenograft tumor models through disruption of tubulin palmitoylation and microtubule organization and FASN inhibition-mediated effects on oncogenic signaling and gene expression

By natalia / 12/2016

EBioMedicine

Preliminary Activity in the First in Human Study of the First-In-Class Fatty Acid Synthase Inhibitor, TVB-2640

By Graviton / 11/2016

NCRI Cancer Conference

Mechanism and rationale for inhibition of FASN as a novel therapy for KRAS-mutant non-small cell lung cancer patients

By natalia / 09/2016

Precison: Lung Cancer R&D Summit

DeNovo Palmitate Synthesis Supports Oncogenic Signaling Through Diverse Mechanisms: Implications for FASN-Targeted Therapeutics

By natalia / 08/2016

Journal of Cell Signaling

Preliminary Activity in the First in Human Study of the First-In-Class Fatty Acid Synthase (FASN) Inhibitor, TVB-2640

By Graviton / 06/2016

ASCO Annual Meeting

FASN inhibitor TVB-2640 shows pharmacodynamic effect and evidence of clinical activity in KRAS mutant NSCLC patients in a Phase 1 study

By Graviton / 04/2016

AACR Annual Meeting

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About
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About
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