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NASH

NASH, PUBLICATIONS

Combination of fatty acid synthase (FASN) inhibitor and thyroid hormone receptor beta (THRb) agonist, resmetirom, improved markers of MASH and cardiovascular health in LDL receptor knockout MASH mice

By charlie maddox / 06/2024

EASL International Liver Congress

NASH, PUBLICATIONS

Denifanstat, a fatty acid synthase (FASN) inhibitor, shows significant fibrosis improvement and MASH resolution in FASCINATE-2, a Ph2b 52 week global, randomized, double blind, placebo-controlled trial in patients with F2 or F3 fibrosis

By charlie maddox / 06/2024

EASL International Liver Congress

Evaluation of FASN inhibitor & GLP-1 Combination in Preclinical Mouse Model

By Graviton / 11/2023

7th Obesity and NASH Drug Development Summit

NASH, PUBLICATIONS

Artificial Intelligence Based Digital Pathology Reveals Fatty Acid Synthase (FASN) Inhibitor Alone or in Combination with Semaglutide Improves Fibrosis in Diet-Induced Obese Mice with Biopsy-Confirmed NASH and Fibrosis

By Graviton / 11/2023

AASLD The Liver Meeting

NASH, PUBLICATIONS

Interim Analysis of FASCINATE-2 A Phase 2b Randomized, Placebo Controlled Trial Demonstrated Denifanstat Reduces Circulating Saturated Diacylglycerols and Triacylglycerols, Markers of Lipotoxicity

By Graviton / 11/2023

AASLD The Liver Meeting

Denifanstat, a fatty acid synthase (FASN) inhibitor for the treatment of biopsy-proven NASH: A 26-week interim analysis of the FASCINATE-2 Phase 2b trial

By Lehi Vidigal / 06/2023

EASL International Liver Congress

Denifanstat (DEN), a first-in-class fatty acid synthase (FASN) inhibitor, significantly reduces plasma tripalmitin, a marker of de novo lipogenesis, in NASH patients in the FASCINATE-1 and FASCINATE-2 clinical studies

By Graviton / 01/2023

NASH-TAG

Serum metabolomic, lipidomic and proteomic profiling identifies new biomarkers associated with the treatment of denifanstat, a fatty acid synthase inhibitor, in NASH patients

By Graviton / 01/2023

NASH-TAG

Correlation between AI-based digital pathology and non-invasive tests (NITs) – baseline data from the FASCINATE-2 phase 2b clinical study of denifanstat in patients with F2/F3 NASH

By Graviton / 11/2022

AASLD The Liver Meeting

A baseline metabolomic signature predicts liver fat (MRI-PDFF) response for denifanstat, a first-in-class, fatty acid synthase (FASN) inhibitor: analysis in FASCINATE-1 and FASCINATE-2 clinical studies

By Graviton / 11/2022

AASLD The Liver Meeting

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