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NASH, PUBLICATIONS

Transcriptomic analysis revealed distinct mechanisms underlying the synergistic effect of a fatty acid synthase (FASN) inhibitor and resmetirom combination in LDL receptor knockout MASH mice

By charlie maddox / 05/2026

EASL International Liver Congress

NASH, PUBLICATIONS

Denifanstat and resmetirom combination therapy rapidly decreased atherogenic lipids in healthy adults in Phase 1 open-label trial

By charlie maddox / 05/2026

EASL International Liver Congress

NASH, PUBLICATIONS

Fatty acid synthase (FASN) inhibitors decreased sebum lipids in human sebocytes via inhibition of de novo lipogenesis, supporting FASN as a target for acne treatment

By charlie maddox / 05/2026

Society for Investigative Dermatology

NASH, PUBLICATIONS

Reduction of plasma glycine- and taurine-conjugated bile acids correlated with histological improvements in denifanstat-treated MASH patients in Phase 2b FASCINATE-2 trial

By charlie maddox / 04/2026

Keystone Symposia

NASH, PUBLICATIONS

Reduction of plasma glycine- and taurine-conjugated bile acids correlated with histological improvements in denifanstat-treated MASH patients in Phase 2b FASCINATE-2 trial

By charlie maddox / 04/2026

Keystone Symposia

NASH, PUBLICATIONS

Denifanstat elicited a significant ≥ 2-stage improvement in fibrosis in F3 MASH patients, and improved liver fibrosis and biomarkers in qFibrosis stage 4 MASH patients: secondary analysis of the phase 2b FASCINATE-2 trial

By charlie maddox / 01/2026

MASH TAG

NASH, PUBLICATIONS

Spatial Computational Histology Stratified Denifanstat Fibrosis Responders in the Phase 2b FASCINATE-2 MASH Trial

By charlie maddox / 11/2025

AASLD The Liver Meeting

NASH, PUBLICATIONS

Denifanstat elicited a significant ≥ 2-stage improvement in fibrosis in F3 MASH patients, and improved liver fibrosis and biomarkers in qFibrosis stage 4 MASH patients: secondary analysis of phase 2b FASCINATE-2 trial

By charlie maddox / 11/2025

AASLD The Liver Meeting

NASH, PUBLICATIONS

FASN Inhibitor Denifanstat Achieved All Endpoints in the Treatment of Acne Vulgaris: Results from a Phase III Randomised Placebo-Controlled Trial

By charlie maddox / 10/2025

2025 Fall Clinical Dermatology Conference

NASH, PUBLICATIONS

Highlighting Mechanism of Action of FASN Inhibitor Denifanstat in MASH

By charlie maddox / 09/2025

9th Annual MASH Drug Development Summit

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