Senior Scientist, R&D

Sagimet Biosciences
Sagimet is a clinical-stage pharmaceutical company developing FASN inhibitors to treat non-alcoholic steatohepatitis (NASH) and various cancers. Our expertise in FASN enables us to break new ground in targeting dysfunctional metabolic pathways. Our lead program is in Phase 2 development.  This scientist will join a successful team and contribute to development of our FASN inhibitors in NASH and in oncology.

Position Summary:
Design, implement and analyze preclinical pharmacology and clinical biomarker studies.

Key Responsibilities include the following:

  • Design and lead pharmacology studies with emphasis on informing mechanism and patient selection in FASN inhibitor clinical programs 
  • Implement biomarker assays and analysis in clinical studies, working with clinical team and CROs
  • Analyze and evaluate data, interpret and present results to development teams
  • Author IND sections, other regulatory documents, study reports and publications
  • Member of multi-disciplinary team designing development strategies in NASH and oncology
  • Work with academic collaborators

Qualifications and skills:

  • PhD with at least 5 years’ experience in drug development, ideally in pharmacology or biomarker sciences.  Expertise in DMPK or toxicology beneficial.
  • Demonstrated ability to manage projects and CROs (all work will be outsourced or via collaborations)
  • Background in oncology or NASH strongly beneficial
  • Thrives in a small company, dynamic environment.  Team-player able to work well across functions
  • Strong data analysis and presentation skills are essential. Well versed in graphing programs.
  • Strong communication and collaborative skills are essential
  • Reports to Vice President, R&D

To apply for this position, please send cover letter and resume to: